Endocrine Abstracts

Despite the importance of the Ret receptor, it is clear that other signal transduction pathways, tyrosine kinase receptors, and tumours suppressor genes are involved in MTC tumorigenesis and progression. Differences in the clinical behaviour of patients harbouring the same Ret mutations may be related to these other genes. Alterations of genes involved in the G1 phase of the cell cycle, including the cyclins, CDKs and CDK inhibitors, are common events in neoplastic development...

Behavior of thyroid function tests in a Brazilian elderly population using Big DataIntroduction: Interpretation of thyroid function data has changed over the last decades with several groups demonstrating changing in the thyroid axis with aging, particularly with a progressive increase in age-related TSH. With the proliferation of studies with large datasets, termed Big Data, sample sizes are no longer a challenge, and the possibility of using clinical l...

Correlation of three thyroglobulin assays in the management of differentiated thyroid cancer (DTC) patientsIntroduction: Thyroglobulin(Tg) is the main biochemical marker of DTC. Usual immunometric assays(IMA) are prone to interference by autoantibodies which can lead to erroneous results. LC-MS/MS has been described as an assay that may provide accurate results, however the literature reported up to 40% of undetectable rates in patients with positive thy...